Description

3-{[4-(tert-Butoxycarbonyl)Piperazin-1-Yl]Carbonyl}-2,2-Dimethylcyclopropanecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropane carboxylic acid core protected by a Boc-piperazine moiety. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) where its rigid, three-membered ring structure and protected amine functionality are essential for imparting specific biological activity and metabolic stability. It is primarily utilized by research organizations and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas such as protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) and investigational new drugs.
• Protease Inhibitor Development: Serves as a crucial precursor in the research and production of protease inhibitor compounds for antiviral and anticancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained cyclopropane geometry and protected amine handle.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.
• Bioconjugation & Linker Chemistry: The carboxylic acid group enables conjugation to other molecules, useful in creating drug-linker complexes for targeted delivery systems.

Basic Information

Item	Details
Product Name	3-{[4-(tert-Butoxycarbonyl)Piperazin-1-Yl]Carbonyl}-2,2-Dimethylcyclopropanecarboxylic Acid
CAS No.	1142215-09-5
Molecular Formula	C16H26N2O5
Molecular Weight	326.39 g/mol
Synonyms	2,2-Dimethyl-3-[(4-[(2-methyl-2-propanyl)oxycarbonyl]-1-piperazinyl)carbonyl]cyclopropanecarboxylic Acid; 3-[(4-Boc-piperazine-1-carbonyl)-2,2-dimethylcyclopropanecarboxylic Acid; 2,2-Dimethyl-3-(4-(tert-butoxycarbonyl)piperazine-1-carbonyl)cyclopropane-1-carboxylic Acid; Boc-Pip-Cyclopropane-COOH; (1R,3S)-rel-3-[[4-[(1,1-Dimethylethoxy)carbonyl]-1-piperazinyl]carbonyl]-2,2-dimethylcyclopropanecarboxylic Acid; 1142215-09-5; tert-Butyl 4-[(2,2-dimethyl-3-carboxycyclopropanecarbonyl)piperazine-1-carboxylate]
EINECS	Contact for details

Quality Control

Our production of 3-{[4-(tert-Butoxycarbonyl)Piperazin-1-Yl]Carbonyl}-2,2-Dimethylcyclopropanecarboxylic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical R&D and cGMP manufacturing. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment, and we support regulatory filings with comprehensive documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.