Description

3-[(4-Acetylpiperazin-1-Yl)Carbonyl]-2,2-Dimethylcyclopropanecarboxylic Acid is a high-purity, synthetically advanced pharmaceutical intermediate with a unique cyclopropane-carboxylic acid core. This compound matters for its role as a critical building block in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries engaged in synthesizing new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel small-molecule drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, or oncology.
• API Synthesis: Used in the research and process development stages for constructing complex molecular scaffolds that incorporate the cyclopropane and piperazine motifs, which are common in modern medicinal chemistry.
• Chemical Biology Research: Employed as a tool compound or a building block for creating chemical probes to study biological pathways and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring high-purity, specialized intermediates.
• Process Chemistry Optimization: Utilized in scaling up synthetic routes from laboratory to pilot plant scale, where consistent quality and purity are paramount.
• Academic Research: Used in university and institutional laboratories for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3-[(4-Acetylpiperazin-1-Yl)Carbonyl]-2,2-Dimethylcyclopropanecarboxylic Acid
CAS No.	1142214-80-9
Molecular Formula	C13H20N2O4
Molecular Weight	268.31 g/mol
Synonyms	2,2-Dimethyl-3-[(4-acetyl-1-piperazinyl)carbonyl]cyclopropanecarboxylic Acid; 2,2-Dimethyl-3-(4-acetylpiperazine-1-carbonyl)cyclopropane-1-carboxylic Acid; 3-(4-Acetylpiperazine-1-carbonyl)-2,2-dimethylcyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 3-[(4-acetyl-1-piperazinyl)carbonyl]-2,2-dimethyl-; (1R,3S)-3-[(4-Acetylpiperazin-1-yl)carbonyl]-2,2-dimethylcyclopropanecarboxylic Acid (for stereoisomer); (1S,3R)-3-[(4-Acetylpiperazin-1-yl)carbonyl]-2,2-dimethylcyclopropanecarboxylic Acid (for stereoisomer); CAS 1142214-80-9
EINECS	Contact for details

Quality Control

Our 3-[(4-Acetylpiperazin-1-Yl)Carbonyl]-2,2-Dimethylcyclopropanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring traceability, consistency, and reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.