Description

tert-Butyl 4-[2-(3-Nitrophenoxy)Ethyl]Tetrahydro-1(2H)-Pyrazinecarboxylate CAS NO 1135283-71-4 is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine and nitrophenoxy functional groups. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug molecules, especially in medicinal chemistry research and development.
• API Synthesis: Used as a building block for constructing the core scaffold of potential new chemical entities (NCEs) in preclinical and clinical development phases.
• Neurological Drug Research: Its structural features make it particularly relevant for the development of compounds targeting neurological and psychiatric conditions.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing of candidate drugs under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services to the biopharma industry.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.

Basic Information

Product Name	tert-Butyl 4-[2-(3-Nitrophenoxy)Ethyl]Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	1135283-71-4
Molecular Formula	C17H25N3O5
Molecular Weight	351.40 g/mol
Synonyms	1-Boc-4-[2-(3-nitrophenoxy)ethyl]piperazine; tert-Butyl 4-(2-(3-nitrophenoxy)ethyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[2-(3-nitrophenoxy)ethyl]piperazine; 4-[2-(3-Nitrophenoxy)ethyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; Boc-4-(2-(3-nitrophenoxy)ethyl)piperazine; 1135283-71-4; Piperazine, 1-(1,1-dimethylethoxy)carbonyl-4-[2-(3-nitrophenoxy)ethyl]-
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[2-(3-Nitrophenoxy)Ethyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.