Description

2-((4-Amino-3-(3-Hydroxyprop-1-Ynyl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Methyl)-5-Methyl-3-o-Tolylquinazolin-4(3H)-One is a sophisticated heterocyclic organic compound, CAS NO 1133837-50-9, designed as a key building block in advanced pharmaceutical research and development. This molecule is valued for its complex polycyclic structure, which serves as a critical pharmacophore in the synthesis of targeted therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in the discovery of novel small-molecule drugs, particularly in oncology and signal transduction inhibition.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potent kinase inhibitors and other targeted cancer therapies.
• Biochemical Research: Used as a high-purity reference standard and probe molecule in enzymatic assays and structure-activity relationship (SAR) studies.
• Medicinal Chemistry: Acts as a core scaffold for the design and optimization of new chemical entities (NCEs) with potential therapeutic applications.
• Preclinical Development: Employed in the synthesis of candidate compounds for pharmacological profiling, toxicology studies, and early-stage drug development.
• Academic Research: Utilized in university and institutional labs for investigating novel heterocyclic chemistry and biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry's outsourced R&D and production needs.

Basic Information

Product Name	2-((4-Amino-3-(3-Hydroxyprop-1-Ynyl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Methyl)-5-Methyl-3-o-Tolylquinazolin-4(3H)-One
CAS No.	1133837-50-9
Molecular Formula	C26H22N8O2
Molecular Weight	478.51 g/mol
Synonyms	5-Methyl-3-(2-methylphenyl)-2-[[4-amino-3-(3-hydroxy-1-propyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-4(3H)-quinazolinone; 2-((4-Amino-3-(3-hydroxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one; 1133837-50-9; Quinazolinone-pyrazolopyrimidine hybrid; Kinase inhibitor intermediate; BBT594 (related research code).
EINECS	Contact for details

Quality Control

Our 2-((4-Amino-3-(3-Hydroxyprop-1-Ynyl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Methyl)-5-Methyl-3-o-Tolylquinazolin-4(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider desiccation and an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.