Description

(R)-3-(4-Aminophenyl)-1,4-Dimethylpiperazin-2-One CAS NO 1133434-21-5 is a chiral, nitrogen-containing heterocyclic compound featuring a piperazinone core substituted with an aminophenyl group. This specific stereochemistry and functional group arrangement make it a valuable and versatile advanced pharmaceutical intermediate for the synthesis of targeted active pharmaceutical ingredients (APIs). It is primarily sought after by research organizations and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring chiral specificity.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the research and production of proprietary APIs.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: A critical reagent for structure-activity relationship (SAR) studies and lead optimization in drug discovery pipelines.
• Preclinical and Clinical Trial Material: Supplied in high-purity grades for the production of materials used in non-clinical and clinical studies.
• Chemical Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(R)-3-(4-Aminophenyl)-1,4-Dimethylpiperazin-2-One
CAS No.	1133434-21-5
Molecular Formula	C12H17N3O
Molecular Weight	219.28 g/mol
Synonyms	(R)-3-(4-Aminophenyl)-1,4-dimethylpiperazin-2-one; (R)-1,4-Dimethyl-3-(4-aminophenyl)piperazin-2-one; 1,4-Dimethyl-3-(4-aminophenyl)-2-piperazinone, (R)-; (R)-enantiomer of 3-(4-Aminophenyl)-1,4-dimethylpiperazin-2-one; (R)-3-(p-Aminophenyl)-1,4-dimethyl-2-piperazinone; (R)-API-DMP Intermediate; Chiral Aminophenyl Dimethylpiperazinone
EINECS	Contact for details

Quality Control

Our production of (R)-3-(4-Aminophenyl)-1,4-Dimethylpiperazin-2-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.