Description

(2R,4R)-Methyl 4-Hydroxypiperidine-2-Carboxylate is a high-purity, stereochemically defined piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, process development, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel therapeutic agents, particularly in central nervous system (CNS) and antiviral drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis to explore new chemical entities.
• Process Chemistry & Scale-Up: Serves as a starting material or advanced intermediate in the optimization and commercial-scale production of APIs.
• Agrochemical Synthesis: Employed in the creation of chiral, bioactive compounds for crop protection products.
• Catalyst & Ligand Preparation: Utilized as a precursor for synthesizing chiral catalysts and ligands used in asymmetric synthesis.
• Academic & Institutional Research: A valuable reagent for methodological development in organic synthesis and stereochemistry studies.

Basic Information

Product Name	(2R,4R)-Methyl 4-Hydroxypiperidine-2-Carboxylate
CAS No.	1103929-18-5
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	Methyl (2R,4R)-4-hydroxypiperidine-2-carboxylate; (2R,4R)-4-Hydroxy-2-piperidinecarboxylic acid methyl ester; (2R,4R)-Methyl 4-hydroxypiperidine-2-carboxylate; (2R,4R)-4-Hydroxypipecolic acid methyl ester; Methyl (2R,4R)-4-hydroxypipecolate; (2R-cis)-Methyl 4-hydroxy-2-piperidinecarboxylate; (2R,4R)-4-Hydroxy-2-piperidinecarboxylic acid, methyl ester
EINECS	Contact for details

Quality Control

Our (2R,4R)-Methyl 4-Hydroxypiperidine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and diastereomeric purity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.