Description

Englerin B is a naturally occurring guaiane sesquiterpene compound, identified by CAS number 1094250-13-1, that has garnered significant interest in pharmacological research. Its primary value lies in its potent and selective agonistic activity against TRPC4/TRPC5 calcium channels, making it a critical tool for studying ion channel function and related disease pathways. This compound is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology, renal diseases, and neurological disorders. Its unique mechanism provides a foundation for exploring novel therapeutic agents and understanding cellular signaling.

Application

• Pharmacological Research: A key reference standard and probe for studying transient receptor potential canonical (TRPC) channels, specifically TRPC4 and TRPC5.
• Oncology Studies: Investigated for its selective cytotoxicity against renal cell carcinoma and other cancer cell lines, serving as a lead compound for anticancer drug discovery.
• Ion Channel Screening: Used in high-throughput screening (HTS) assays to identify modulators of TRPC4/5 channels for potential therapeutic intervention.
• Neurological Research: Employed in studies exploring the role of TRPC channels in neurological conditions such as anxiety, depression, and epilepsy.
• Biochemical Pathway Analysis: A tool compound for elucidating calcium signaling pathways and their impact on cell proliferation, migration, and apoptosis.
• Academic & Institutional R&D: Supplied to universities and research institutes for fundamental studies in chemical biology and medicinal chemistry.

Basic Information

Product Name	Englerin B
CAS No.	1094250-13-1
Molecular Formula	C15H22O4
Molecular Weight	266.33 g/mol
Synonyms	Englerin B; (1R,4S,5S,7R,10S)-4,10-Epoxy-1H-5,7-guaianediol, 1,5-diacetate; Guaiane-1,5-diol, 4,10-epoxy-, 1,5-diacetate, (1R,4S,5S,7R,10S)-; Englerin B (natural product); TRPC4/5 channel agonist; (-)-Englerin B
EINECS	Contact for details

Quality Control

Every batch of Englerin B is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and structural confirmation, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for purity, identity, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.