Description

Bis-Propargyl-Peg9 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring terminal propargyl groups. This compound is specifically engineered as a versatile linker for advanced bioconjugation and materials science applications, enabling precise, site-specific coupling via click chemistry. It is essential for researchers and manufacturers in pharmaceutical development, diagnostic assay creation, and the synthesis of functionalized hydrogels and nanomaterials.

Application

• Bioconjugation Linker: For site-specific coupling of peptides, proteins, antibodies, or oligonucleotides using copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted variants.
• PEGylation Reagent: To introduce PEG chains with reactive alkyne handles onto drug molecules or therapeutic proteins, enhancing solubility and pharmacokinetics.
• Polymer & Material Science: As a cross-linking agent or initiator in the synthesis of smart hydrogels, responsive polymers, and functional surface coatings.
• Diagnostic Probes: In the development of fluorescent, enzymatic, or radioactive diagnostic labels and imaging agents.
• ADC (Antibody-Drug Conjugate) Development: As a component of linker-payload systems for constructing next-generation targeted cancer therapies.
• Nanoparticle Functionalization: For attaching targeting ligands or therapeutic cargo to liposomes, dendrimers, or other nanocarriers.
• Solid-Phase Synthesis Support: As a soluble polymer support for combinatorial chemistry and peptide synthesis.
• Click Chemistry Tool: A fundamental building block in academic and industrial research utilizing bioorthogonal chemistry methodologies.

Basic Information

Product Name	Bis-Propargyl-Peg9
CAS No.	1092554-87-4
Molecular Formula	C24H42O10
Molecular Weight	490.59 g/mol
Synonyms	Propargyl-PEG9-propargyl; α,ω-Bis(2-propyn-1-yloxy)nonakis(oxyethylene); PEG9 bis(propargyl) ether; Bis-propargyl PEG 450; 1,1'-[1,11-(3,6,9-Trioxaundecane-1,11-diyl)bis(oxy)]bis[2-propyn]; 2,5,8,11,14,17,20,23,26-Nonaoxaoctacos-27-yne-1,28-diyl bis(2-propyn-1-yl ether); Alkyne-PEG9-alkyne; DBCO-PEG9-DBCO precursor
EINECS	Contact for details

Quality Control

Our Bis-Propargyl-Peg9 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) are provided, detailing specifications for identity, purity (by HPLC/NMR), and functional group integrity. We support compliance with cGMP and ISO 9001 standards for pharmaceutical and industrial customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Functional Group (Alkyne)	≥ 90% of theory
Average Molecular Weight	490 ± 20 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.