Description

3-Chloro-4-(Trifluoromethyl)Benzoyl Fluoride is a high-value fluorinated aromatic building block, essential for introducing the benzoyl fluoride moiety into complex molecular architectures. Its primary commercial value lies in its dual functional groups, making it a versatile intermediate for synthesizing advanced agrochemicals and active pharmaceutical ingredients (APIs). This compound is particularly critical for research and production chemists in the fine chemical and pharmaceutical industries seeking to develop novel compounds with enhanced biological activity and stability.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of modern herbicides, fungicides, and insecticides, where the trifluoromethyl and chloro groups contribute to lipophilicity and metabolic stability.
• Pharmaceutical Synthesis: Serves as a crucial building block for creating novel drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory therapies.
• Liquid Crystal Materials: Used in the production of fluorinated liquid crystals for advanced display technologies, leveraging its stable aromatic core and fluorine content.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers, including high-performance resins and coatings with unique chemical resistance.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitution to construct complex, fluorinated biaryl systems.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethyl)Benzoyl Fluoride
CAS No.	1092460-77-9
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	3-Chloro-4-(trifluoromethyl)benzoyl fluoride; 4-Chloro-α,α,α-trifluoro-m-toluoyl fluoride; 2-Chloro-α,α,α-trifluoro-p-toluoyl fluoride; Benzoyl fluoride, 3-chloro-4-(trifluoromethyl)-; 3-Chloro-4-trifluoromethylbenzoyl fluoride; 1092460-77-9; m-Chloro-α,α,α-trifluoro-p-toluoyl fluoride
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(Trifluoromethyl)Benzoyl Fluoride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.