Description

(R)-Octahydro-Pyrrolo[1,2-A]Pyrazine Dihydrochloride CAS NO 1092076-07-7 is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in its role as a key precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex, stereochemically defined heterocyclic scaffolds. This compound is essential for research and development chemists in the pharmaceutical, biotechnology, and fine chemical industries seeking to synthesize advanced molecules with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Asymmetric Synthesis: Serves as a versatile building block in the construction of complex, enantiomerically pure molecules for medicinal chemistry programs.
• Ligand and Catalyst Development: Used in the research and preparation of chiral ligands and organocatalysts for asymmetric transformations.
• Peptidomimetic Research: Acts as a constrained, bicyclic diamine scaffold for designing and synthesizing peptidomimetics and protease inhibitors.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing GMP-grade intermediates.

Basic Information

Item	Details
Product Name	(R)-Octahydro-Pyrrolo[1,2-A]Pyrazine Dihydrochloride
CAS No.	1092076-07-7
Molecular Formula	C7H16Cl2N2
Molecular Weight	199.12 g/mol
Synonyms	(R)-Octahydropyrrolo[1,2-a]pyrazine dihydrochloride; (R)-1,2,3,4,6,7,8,8a-Octahydropyrrolo[1,2-a]pyrazine dihydrochloride; (R)-Perhydropyrrolo[1,2-a]pyrazine dihydrochloride; (R)-Hexahydro-1H-pyrrolo[1,2-a]pyrazine dihydrochloride; (R)-PPZ dihydrochloride; (R)-Bicyclo[3.3.0]octane-2,6-diamine dihydrochloride (derived); (R)-2,6-Diazabicyclo[3.3.0]octane dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Octahydro-Pyrrolo[1,2-A]Pyrazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.