Description

2-Bromo-6-Cyclopropylpyrazine is a high-purity, functionalized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate, enabling the precise introduction of both bromine and cyclopropyl functionalities into complex molecular architectures. It is primarily needed by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, particularly in medicinal chemistry for creating targeted small-molecule libraries.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides that leverage the unique properties of the pyrazine and cyclopropyl groups.
• Material Science Research: Serves as a precursor for the synthesis of specialized ligands, organic semiconductors, and other functional materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Medicinal Chemistry Library Construction: Employed in parallel and combinatorial synthesis to generate diverse compound sets for high-throughput screening (HTS).
• Chemical Biology Probes: Used to develop molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-Bromo-6-Cyclopropylpyrazine
CAS No.	1086382-98-0
Molecular Formula	C7H7BrN2
Molecular Weight	199.05 g/mol
Synonyms	6-Cyclopropyl-2-bromopyrazine; 2-Bromo-6-cyclopropylpyrazine; Pyrazine, 2-bromo-6-cyclopropyl-; Bromocyclopropylpyrazine; 1086382-98-0; 2-Bromo-6-cyclopropyl-pyrazine; (6-Cyclopropylpyrazin-2-yl)bromide
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Cyclopropylpyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with the standards required for research and cGMP intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.