Description

tert-Butyl 4-[2-(4-Formylphenoxy)-Ethyl]Piperazine-1-Carboxylate is a high-value, multi-functional piperazine derivative featuring both a formyl (aldehyde) group and a tert-butoxycarbonyl (Boc) protecting group. This compound matters as a versatile and critical building block in modern organic synthesis, enabling the controlled construction of complex molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, particularly as a key intermediate in the synthesis of kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of small molecule drug candidates, especially protein kinase inhibitors and receptor antagonists.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Serves as a scaffold for designing molecular probes and activity-based protein profiling (ABPP) reagents.
• Peptidomimetics & Macrocycle Synthesis: The aldehyde group allows for conjugation via reductive amination, while the Boc group provides orthogonal protection for piperazine nitrogen.
• Material Science Precursor: Potential use in the synthesis of functional polymers and ligands for metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring this precise molecular architecture.

Basic Information

Product Name	tert-Butyl 4-[2-(4-Formylphenoxy)-Ethyl]Piperazine-1-Carboxylate
CAS No.	1086378-39-3
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	1-Boc-4-[2-(4-formylphenoxy)ethyl]piperazine; 4-[2-(4-Formylphenoxy)ethyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(2-(4-formylphenoxy)ethyl)piperazine-1-carboxylate; BOC-4-(2-(4-Formylphenoxy)ethyl)piperazine; 1-(tert-Butoxycarbonyl)-4-[2-(4-formylphenoxy)ethyl]piperazine; 4-(2-(4-Formylphenoxy)ethyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[2-(4-Formylphenoxy)-Ethyl]Piperazine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full batch traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.