Description

10-Methyl-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline CAS NO 1082871-89-3 is a complex, heterocyclic organic compound belonging to the pyrazinoisoquinoline class, serving as a critical advanced intermediate in modern synthetic chemistry. Its intricate fused-ring structure makes it a valuable scaffold for pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). This high-purity building block is essential for medicinal chemists and process development scientists working in drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the optimization and commercial-scale production of target APIs.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring high-purity, specialized heterocycles.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and methodological development.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or tagged molecules for biological studies due to its functionalizable nitrogen atoms.

Basic Information

Product Name	10-Methyl-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline
CAS No.	1082871-89-3
Molecular Formula	C₁₄H₂₀N₂
Molecular Weight	216.32 g/mol
Synonyms	10-Methyl-1,2,3,4,6,7-hexahydropyrazino[2,1-a]isoquinoline; 10-Methyl-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinoline; Pyrazino[2,1-a]isoquinoline, 2,3,4,6,7,11b-hexahydro-10-methyl-1H-; 1H-Pyrazino[2,1-a]isoquinoline, 2,3,4,6,7,11b-hexahydro-10-methyl-; 1082871-89-3 (CAS); 10-Methylhexahydropyrazinoisoquinoline
EINECS	Contact for details

Quality Control

Our 10-Methyl-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring the material is suitable for demanding applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider holding under an inert atmosphere to maximize stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.