Description

10-Methyl-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one is a high-purity, advanced pharmaceutical intermediate belonging to the fused tetrahydropyrazino-isoquinolinone class of heterocyclic compounds. Its complex, polycyclic structure makes it a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system and other therapeutic areas. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology industries seeking to develop new drug candidates with enhanced efficacy and selectivity.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, particularly those with neurological activity.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the discovery of new bioactive compounds.
• Process Development & Scale-Up: Serves as a critical material for optimizing synthetic routes and scaling production from laboratory to pilot plant and commercial manufacturing.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API production.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	10-Methyl-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one
CAS No.	1082871-84-8
Molecular Formula	C₁₄H₁₆N₂O
Molecular Weight	228.29 g/mol
Synonyms	10-Methyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one; 10-Methyl-2,3,6,7-tetrahydro-1H,4H,11bH-pyrazino[2,1-a]isoquinolin-4-one; 10-Methyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one; Pyrazino[2,1-a]isoquinolin-4(11bH)-one, 2,3,6,7-tetrahydro-10-methyl-1H-; CAS 1082871-84-8
EINECS	Contact for details

Quality Control

Our production of 10-Methyl-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect this compound from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.