Description

2,2-Dimethyl-1-{4-[(1-Methyl-1H-Indol-2-Yl)Carbonyl]Piperazin-1-Yl}Propan-1-One is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture combining indole and piperazine motifs. This compound is of significant value for its role as a key building block in the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery pipelines. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies to optimize potency and selectivity of new chemical entities.
• Biochemical Tool Compound: Employed in vitro and in vivo to study biological pathways and validate novel drug targets within academic and industrial research settings.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Item	Details
Product Name	2,2-Dimethyl-1-{4-[(1-Methyl-1H-Indol-2-Yl)Carbonyl]Piperazin-1-Yl}Propan-1-One
CAS No.	1081116-83-7
Molecular Formula	C19H25N3O2
Molecular Weight	327.42 g/mol
Synonyms	2,2-Dimethyl-1-[4-[(1-methylindol-2-yl)carbonyl]piperazin-1-yl]propan-1-one; 1-(1-Methyl-1H-indole-2-carbonyl)-4-(2,2-dimethylpropionyl)piperazine; 2,2-Dimethyl-1-(4-((1-methyl-1H-indol-2-yl)carbonyl)piperazin-1-yl)propan-1-one; UNII-1J4J9Q6B4F; 1J4J9Q6B4F; Propan-1-one, 2,2-dimethyl-1-[4-[(1-methyl-1H-indol-2-yl)carbonyl]-1-piperazinyl]-
EINECS	Contact for details

Quality Control

Our 2,2-Dimethyl-1-{4-[(1-Methyl-1H-Indol-2-Yl)Carbonyl]Piperazin-1-Yl}Propan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.