Description

Saxagliptin CAS NO 1073057-20-1 is a potent, selective, and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. This compound is a critical active pharmaceutical ingredient (API) used in the management of type 2 diabetes mellitus. It is essential for pharmaceutical manufacturers and research institutions developing innovative antidiabetic therapies. Our supply ensures high purity and consistent quality for reliable formulation and research outcomes.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the manufacture of oral antidiabetic medications.
• Formulation of fixed-dose combination drugs with other antihyperglycemic agents like metformin.
• Reference standard for analytical testing and quality control in pharmaceutical laboratories.
• Key intermediate in advanced pharmaceutical research and development of new DPP-4 inhibitors.
• Biochemical research tool for studying the role of DPP-4 in glucose metabolism and related pathways.

Basic Information

Product Name	Saxagliptin
CAS No.	1073057-20-1
Molecular Formula	C18H25N3O2
Molecular Weight	315.41 g/mol
Synonyms	(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; BMS-477118; Onglyza (Trade Name); (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
EINECS	Contact for details

Quality Control

Our Saxagliptin is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral methods for enantiomeric excess, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) that comply with current pharmacopeial standards (USP/EP) and ICH guidelines to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	NMT 20 ppm
Specific Rotation	+158° to +168° (c=1, in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.