Description

Pyrrolo[1,2-A]Pyrazin-7-Ol, Octahydro-, Hydrochloride (1:2), (7R,8As)- is a high-purity, stereochemically defined chemical building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral intermediate for the synthesis of complex molecules, particularly in the discovery of new therapeutic agents targeting the central nervous system and other disease areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in process chemistry and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities with potential therapeutic effects.
• Process Development: Serves as a starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Asymmetric Synthesis: Exploited for its defined stereochemistry to introduce chiral complexity into target molecules, ensuring high enantiomeric purity in the final product.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development, quality control, and regulatory filing support.

Basic Information

Product Name	Pyrrolo[1,2-A]Pyrazin-7-Ol, Octahydro-, Hydrochloride (1:2), (7R,8As)-
CAS No.	1070165-89-7
Molecular Formula	C7H13N2O · 2HCl
Molecular Weight	225.11 g/mol (Free base: 141.19 g/mol)
Synonyms	(7R,8aS)-Octahydropyrrolo[1,2-a]pyrazin-7-ol dihydrochloride; (7R,8aS)-Octahydro-1H-pyrrolo[1,2-a]pyrazin-7-ol hydrochloride (1:2); Pyrrolo[1,2-a]pyrazin-7-ol, octahydro-, hydrochloride (1:2), (7R,8aS)-; 1070165-89-7; (7R,8aS)-Octahydropyrrolo[1,2-a]pyrazin-7-ol, 2HCl
EINECS	Contact for details

Quality Control

Our Pyrrolo[1,2-A]Pyrazin-7-Ol, Octahydro-, Hydrochloride (1:2), (7R,8As)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.