Description

tert-Butyl 3,3-Difluoro-4,4-Dihydroxypiperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorinated piperidine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and membrane permeability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new drug candidates, particularly in therapeutic areas requiring sophisticated fluorine chemistry.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorine atoms for improved drug-like properties.
• Protease Inhibitor Development: Serves as a core scaffold in the research of inhibitors targeting various proteases.
• Fluorine Chemistry Synthesis: An essential reagent for introducing the 3,3-difluoro-4,4-dihydroxypiperidine moiety into complex organic molecules.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Details
Product Name	tert-Butyl 3,3-Difluoro-4,4-Dihydroxypiperidine-1-Carboxylate
CAS No.	1067914-83-3
Molecular Formula	C10H17F2NO4
Molecular Weight	253.24 g/mol
Synonyms	1-Boc-3,3-difluoro-4,4-dihydroxypiperidine; 1-(tert-Butoxycarbonyl)-3,3-difluoro-4,4-dihydroxypiperidine; 3,3-Difluoro-4,4-dihydroxy-1-piperidinecarboxylic acid tert-butyl ester; tert-Butyl 3,3-difluoro-4,4-dihydroxy-1-piperidinecarboxylate; 1-N-Boc-3,3-difluoro-4,4-dihydroxypiperidine; 4,4-Dihydroxy-3,3-difluoropiperidine-1-carboxylic acid tert-butyl ester; Boc-3,3-difluoro-4,4-dihydroxypiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,3-Difluoro-4,4-Dihydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are available for every lot to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.