Description

tert-Butyl 4-(3-Nitropyridin-4-Ylamino)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group and functionalized with a nitropyridine moiety. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing therapeutic agents, particularly in areas such as kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting protein kinases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new therapeutic molecules.
• API Synthesis: Serves as a protected amine intermediate in the production of Active Pharmaceutical Ingredients (APIs) requiring a functionalized piperidine scaffold.
• Chemical Biology Probes: Employed in the development of chemical probes for studying biological pathways and target validation.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 4-(3-Nitropyridin-4-Ylamino)Piperidine-1-Carboxylate
CAS No.	1067718-07-3
Molecular Formula	C15H22N4O4
Molecular Weight	322.36 g/mol
Synonyms	1-Boc-4-((3-nitropyridin-4-yl)amino)piperidine; 4-[(3-Nitro-4-pyridinyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-[(3-nitropyridin-4-yl)amino]piperidine-1-carboxylate; 1,1-Dimethylethyl 4-[(3-nitro-4-pyridinyl)amino]-1-piperidinecarboxylate; 4-(3-Nitropyridin-4-ylamino)piperidine-1-carboxylic acid tert-butyl ester; 1067718-07-3; Boc-4-(3-nitro-4-aminopyridine)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-Nitropyridin-4-Ylamino)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring the material is suitable for advanced research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.