Description

3-Iodopyrazine-2-Carbonitrile is a versatile and high-value halogenated heterocyclic building block, essential for advanced organic synthesis. Its unique structure, featuring both an iodine atom and a nitrile group on the pyrazine ring, makes it a critical intermediate for constructing complex molecules with precision. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Serves as a building block for creating specialized ligands, organic semiconductors, and photoactive materials.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings to introduce the pyrazine-carbonitrile scaffold.
• Nitrile Functionalization: The cyano group can be further transformed into amides, acids, tetrazoles, and other heterocycles, expanding molecular diversity.

Basic Information

Product Name	3-Iodopyrazine-2-Carbonitrile
CAS No.	1062608-54-1
Molecular Formula	C5H2IN3
Molecular Weight	230.99 g/mol
Synonyms	3-Iodopyrazine-2-carbonitrile; 2-Cyano-3-iodopyrazine; Pyrazine-2-carbonitrile, 3-iodo-; 3-Iodo-2-pyrazinecarbonitrile; 3-Iodopyrazinecarbonitrile; 1062608-54-1; AI3-32921; AKOS040759623; ZINC000257830803; SCHEMBL15507795; CTK8G8065; MolPort-044-690-947
EINECS	Contact for details

Quality Control

Our 3-Iodopyrazine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles to meet your specific R&D or scale-up requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.