Description

5-(Trifluoromethyl)Pyrazine-2-Carboxylic Acid is a high-value trifluoromethylated heterocyclic building block essential for modern synthetic chemistry. This compound matters because the trifluoromethyl group imparts unique physicochemical properties, such as enhanced metabolic stability and lipophilicity, which are critical for developing advanced materials and bioactive molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Research: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the CF3 group can improve biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for constructing sophisticated pyrazine-based ligands used in catalysis and material science.
• Functional Material Synthesis: Employed in the creation of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized to synthesize molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-(Trifluoromethyl)Pyrazine-2-Carboxylic Acid
CAS No.	1060814-50-7
Molecular Formula	C6H3F3N2O2
Molecular Weight	192.10 g/mol
Synonyms	2-Pyrazinecarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-pyrazinecarboxylic acid; 5-Trifluoromethylpyrazine-2-carboxylic acid; 5-Trifluoromethyl-2-pyrazinecarboxylic acid; 5-(Trifluoromethyl)pyrazine-2-carboxylic acid; 1060814-50-7; 5-Carboxy-2-trifluoromethylpyrazine
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Pyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.