Description

6-(Trifluoromethyl)Pyrazine-2-Carboxylic Acid is a high-value fluorinated pyrazine derivative that serves as a critical building block in advanced organic synthesis. This compound is prized for its ability to introduce both a trifluoromethyl group and a carboxylic acid functionality, enabling precise modulation of molecular properties such as lipophilicity, metabolic stability, and binding affinity. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of functionalized heterocyclic compounds for electronic materials and organic semiconductors.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Item	Details
Product Name	6-(Trifluoromethyl)Pyrazine-2-Carboxylic Acid
CAS No.	1060812-74-9
Molecular Formula	C6H3F3N2O2
Molecular Weight	192.10 g/mol
Synonyms	2-Pyrazinecarboxylic acid, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)-2-pyrazinecarboxylic acid; 6-Trifluoromethylpyrazine-2-carboxylic acid; 2-Carboxy-6-trifluoromethylpyrazine; 1060812-74-9
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our standard grade for 6-(Trifluoromethyl)Pyrazine-2-Carboxylic Acid typically meets a purity specification of ≥97% (by HPLC), with comprehensive identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and physical characteristics. Specifications can be customized to meet specific project requirements, including higher purity grades for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.