Description

2-(Chloromethyl)-5-(Trifluoromethyl)Pyrazine is a versatile and high-value pyrazine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive chloromethyl group and a stable trifluoromethyl moiety, makes it indispensable for introducing specific functionalities into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for constructing complex heterocyclic ligands used in catalysis and material science.
• Functional Material Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or charge-transport layers, due to its electron-deficient pyrazine core.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-(Chloromethyl)-5-(Trifluoromethyl)Pyrazine
CAS No.	1060812-69-2
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	5-(Trifluoromethyl)-2-pyrazinemethane chloride; 2-(Chloromethyl)-5-(trifluoromethyl)pyrazine; 2-Chloromethyl-5-trifluoromethylpyrazine; (5-Trifluoromethyl-pyrazin-2-yl)-chloromethane; 1060812-69-2; 5-(Trifluoromethyl)-2-(chloromethyl)pyrazine
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemical intermediates. Production of 2-(Chloromethyl)-5-(Trifluoromethyl)Pyrazine is monitored through in-process controls and validated analytical methods, including HPLC, GC, and NMR, to ensure batch-to-batch consistency and high purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.