Description

2-Bromo-5-Piperidin-1-Ylpyrazine CAS NO 1060803-86-2 is a high-value heterocyclic building block featuring a brominated pyrazine core substituted with a piperidine moiety. This compound is essential for medicinal chemistry research and development, serving as a versatile intermediate for constructing novel pharmacologically active molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on creating new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule drug candidates, especially kinase inhibitors and modulators of neurological targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Agrochemical Development: Serves as a building block for creating novel active ingredients in crop protection research.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.
• Library Synthesis: Employed in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.
• Process Chemistry: Acts as a critical intermediate in the scale-up and route development for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Bromo-5-Piperidin-1-Ylpyrazine
CAS No.	1060803-86-2
Molecular Formula	C9H12BrN3
Molecular Weight	242.12 g/mol
Synonyms	2-Bromo-5-(piperidin-1-yl)pyrazine; 5-(Piperidin-1-yl)-2-bromopyrazine; 2-Bromo-5-(1-piperidinyl)pyrazine; Pyrazine, 2-bromo-5-(1-piperidinyl)-; 1060803-86-2; 2-Bromo-5-piperidin-1-yl-pyrazine; 2-Bromo-5-(N-piperidino)pyrazine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Piperidin-1-Ylpyrazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.