Description

2-Bromo-5-Ethoxypyrazine is a high-purity halogenated pyrazine derivative, a key building block in advanced organic synthesis. Its value lies in its unique reactivity, where the bromine atom serves as an excellent leaving group for cross-coupling reactions, while the ethoxy substituent modulates electronic properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the pyrazine core's bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: An effective substrate in Suzuki, Stille, and Buchwald-Hartwig amination reactions to form new carbon-carbon and carbon-nitrogen bonds.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands for metal catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	2-Bromo-5-Ethoxypyrazine
CAS No.	1060803-83-9
Molecular Formula	C6H7BrN2O
Molecular Weight	203.04 g/mol
Synonyms	5-Ethoxy-2-bromopyrazine; 2-Bromo-5-ethoxypyrazine; Pyrazine, 2-bromo-5-ethoxy-; 5-Ethoxy-2-brompyrazin (German); 5-エトキシ-2-ブロモピラジン (Japanese); 1060803-83-9; Bromoethoxy pyrazine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Ethoxypyrazine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.