Description

4-Piperidinecarboxylic Acid, 1-[[4-(4-Hydroxy-1-Butyn-1-Yl)Phenyl]Methyl]-4-[[3-(Trifluoromethyl)Phenyl]Methyl]-, Ethyl Ester is a high-value, complex organic intermediate featuring a piperidine core with distinct aryl and trifluoromethyl substituents. This compound matters for its role as a critical building block in modern pharmaceutical research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries working on novel drug candidates.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probe Synthesis: Serves as a building block for creating molecular probes to study biological pathways and protein function.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale manufacturing of advanced drug candidates.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Item	Details
Product Name	4-Piperidinecarboxylic Acid, 1-[[4-(4-Hydroxy-1-Butyn-1-Yl)Phenyl]Methyl]-4-[[3-(Trifluoromethyl)Phenyl]Methyl]-, Ethyl Ester
CAS No.	1060376-43-3
Molecular Formula	C27H28F3NO3
Molecular Weight	471.51 g/mol
Synonyms	1-[(4-{4-Hydroxybut-1-yn-1-yl}benzyl)-4-{[3-(trifluoromethyl)phenyl]methyl}piperidine-4-carboxylic acid ethyl ester; Ethyl 1-((4-(4-hydroxybut-1-yn-1-yl)benzyl)-4-((3-(trifluoromethyl)benzyl)piperidine-4-carboxylate; 1-[[4-(4-Hydroxy-1-butynyl)phenyl]methyl]-4-[[3-(trifluoromethyl)phenyl]methyl]-4-piperidinecarboxylic acid ethyl ester; 4-Piperidinecarboxylic acid, 1-[(4-(4-hydroxy-1-butyn-1-yl)phenyl)methyl]-4-[[3-(trifluoromethyl)phenyl]methyl]-, ethyl ester; CAS 1060376-43-3
EINECS	Contact for details

Quality Control

Our 4-Piperidinecarboxylic Acid, 1-[[4-(4-Hydroxy-1-Butyn-1-Yl)Phenyl]Methyl]-4-[[3-(Trifluoromethyl)Phenyl]Methyl]-, Ethyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.