Description

2-Chloro-5-Iodopyrazine is a halogenated pyrazine derivative serving as a versatile and high-value synthetic building block in advanced organic chemistry. Its molecular structure, featuring both chlorine and iodine substituents, makes it a critical intermediate for constructing complex molecules through selective cross-coupling and functional group transformations. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring halogenated heterocyclic cores.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialized organic electronic materials and ligands for catalysis.
• Cross-Coupling Reactions: The iodine moiety is highly reactive in palladium-catalyzed couplings (e.g., Suzuki, Sonogashira, Negishi), while the chlorine allows for sequential functionalization.
• Chemical Research & Development: A valuable reagent for method development in organic synthesis and for creating focused libraries of compounds for biological screening.
• Ligand Synthesis: Used to prepare sophisticated polydentate ligands for coordination chemistry and homogeneous catalysis.

Basic Information

Product Name	2-Chloro-5-Iodopyrazine
CAS No.	1057216-55-3
Molecular Formula	C4H2ClIN2
Molecular Weight	240.43 g/mol
Synonyms	5-Iodo-2-chloropyrazine; 2-Chloro-5-iodopyrazine; Pyrazine, 2-chloro-5-iodo-; 2-Chlor-5-jodpyrazin (German); 2-クロロ-5-ヨードピラジン (Japanese); 2-氯-5-碘吡嗪 (Chinese); 1057216-55-3 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Iodopyrazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.