Description

25-Bromo-2,5,8,11,14,17,20,23-Octaoxapentacosane is a specialized brominated polyethylene glycol (PEG) derivative, serving as a valuable bifunctional linker and intermediate in advanced organic synthesis. Its core value lies in its unique structure, which combines a reactive bromoalkyl terminus with a hydrophilic PEG spacer chain, enabling precise conjugation and solubilization strategies. This compound is essential for researchers and manufacturers in pharmaceuticals, bioconjugation, and materials science who require controlled functionalization and modification of molecules, polymers, and surfaces.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of antibody-drug conjugates (ADCs), prodrugs, and targeted therapeutic agents.
• Bioconjugation Reagent: Used to attach drugs, dyes, or other functional molecules to proteins, peptides, or nanoparticles via the reactive bromo group.
• Polymer Chemistry: Serves as a macro-initiator or chain transfer agent in controlled radical polymerizations (e.g., ATRP) to create PEG-based block copolymers.
• Surface Modification: Employed to functionalize materials and surfaces with PEG brushes to impart biocompatibility, anti-fouling properties, or specific reactivity.
• Crosslinking Agent: Utilized in the formation of hydrogels, polymer networks, and dendrimers due to its bifunctional nature.
• Solubility Enhancer: The PEG chain can be used to improve the aqueous solubility of hydrophobic drug candidates or organic compounds.
• Ligand Synthesis: Intermediate for creating PEGylated ligands, chelators, and catalysts used in diagnostic imaging and catalysis.

Basic Information

Product Name	25-Bromo-2,5,8,11,14,17,20,23-Octaoxapentacosane
CAS No.	1056881-04-9
Molecular Formula	C17H35BrO8
Molecular Weight	447.36 g/mol
Synonyms	Br-PEG8-CH2CH3; 2-[2-[2-[2-[2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; 1-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosan-25-ol; Bromo-PEG8-ethanol; Bromo-terminated octaethylene glycol; 25-Bromo-3,6,9,12,15,18,21,24-octaoxapentacosan-1-ol; Poly(ethylene glycol) methyl ether brominated (n~8); Bromo-PEG8-OH
EINECS	Contact for details

Quality Control

Our 25-Bromo-2,5,8,11,14,17,20,23-Octaoxapentacosane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and titration methods, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Bromine Content	Calculated value ± 2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.