Description

tert-Butyl (3-Oxopiperazin-1-Yl)Acetate is a high-purity, advanced pharmaceutical intermediate characterized by its piperazinone core and tert-butyl ester protecting group. This compound is of significant value in medicinal chemistry for the synthesis of complex bioactive molecules, particularly protease inhibitors and other targeted therapeutics. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, where its consistent quality and reliable supply are critical for process scalability and regulatory compliance.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting enzymatic pathways.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors for therapeutic applications.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Peptidomimetic Synthesis: Employed in the creation of peptidomimetics, which are molecules that mimic peptides but with enhanced stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity intermediates.
• Academic Research: Utilized in university and institutional labs for exploratory research in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	tert-Butyl (3-Oxopiperazin-1-Yl)Acetate
CAS No.	1056057-55-6
Molecular Formula	C10H18N2O3
Molecular Weight	214.26 g/mol
Synonyms	1-(2-tert-Butoxy-2-oxoethyl)-3-oxopiperazine; 2-(3-Oxopiperazin-1-yl)acetic acid tert-butyl ester; tert-Butyl 2-(3-oxopiperazin-1-yl)acetate; 1-(tert-Butoxycarbonylmethyl)-3-oxopiperazine; 3-Oxo-1-piperazineacetic acid tert-butyl ester; (3-Oxopiperazin-1-yl)acetic acid tert-butyl ester; tert-Butyl (3-oxo-1-piperazinyl)acetate
EINECS	Contact for details

Quality Control

Our tert-Butyl (3-Oxopiperazin-1-Yl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' needs for reliable and traceable materials in critical development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.