Description

1-(2,3-Dihydro-1-Benzofuran-5-Ylmethyl)Piperazine Dihydrochloride is a high-purity, versatile heterocyclic building block and intermediate of significant importance in advanced organic synthesis. Its molecular architecture, featuring both a benzofuran and a piperazine moiety, makes it a critical precursor for the development of novel pharmacologically active compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to develop new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, particularly those targeting central nervous system (CNS) disorders, due to its privileged piperazine-benzofuran scaffold.
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and fungicides, where its heterocyclic structure can contribute to biological activity.
• Chemical Research & Development: Serves as a versatile synthon in academic and industrial R&D for constructing complex molecular libraries for high-throughput screening.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, dyes, and advanced materials requiring specific heterocyclic frameworks.
• Ligand and Catalyst Development: The piperazine nitrogen atoms can be functionalized to create novel ligands for metal catalysis or molecular recognition applications.

Basic Information

Product Name	1-(2,3-Dihydro-1-Benzofuran-5-Ylmethyl)Piperazine Dihydrochloride
CAS No.	1052545-84-2
Molecular Formula	C14H20N2O • 2HCl
Molecular Weight	313.25 g/mol (for dihydrochloride salt)
Synonyms	1-[(2,3-Dihydro-1-benzofuran-5-yl)methyl]piperazine dihydrochloride; 5-[(Piperazin-1-yl)methyl]-2,3-dihydro-1-benzofuran dihydrochloride; 1-(2,3-Dihydrobenzofuran-5-ylmethyl)piperazine dihydrochloride; 1-(2,3-Dihydro-1-benzofuran-5-ylmethyl)piperazine HCl salt; Piperazine, 1-[(2,3-dihydro-5-benzofuranyl)methyl]-, dihydrochloride; 1052545-84-2 (CAS); DBF-Piperazine dihydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2,3-Dihydro-1-Benzofuran-5-Ylmethyl)Piperazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.