Description

1-[[2-(4-Methoxyphenyl)-1,3-Thiazol-4-Yl]Methyl]Piperazine Hydrochloride is a high-purity, non-racemic organic compound with a complex heterocyclic structure, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of novel, potent therapeutic agents, particularly in central nervous system (CNS) and oncology research. This product is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates targeting specific receptors.
• CNS Drug Research: Used in the development of potential therapeutics for neurological disorders, acting as a core structural motif.
• Oncology Research: Serves as a precursor for molecules designed to inhibit specific enzymatic pathways involved in cancer cell proliferation.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used for scaling up synthetic routes from milligram to kilogram scale under current Good Manufacturing Practices (cGMP) for clinical trial material supply.
• Reference Standard: High-purity material suitable for use as an analytical standard in method development and quality control for API manufacturing.

Basic Information

Product Name	1-[[2-(4-Methoxyphenyl)-1,3-Thiazol-4-Yl]Methyl]Piperazine Hydrochloride
CAS No.	1052544-34-9
Molecular Formula	C16H22ClN3OS
Molecular Weight	339.88 g/mol
Synonyms	1-{[2-(4-Methoxyphenyl)-1,3-thiazol-4-yl]methyl}piperazine hydrochloride; 4-{[2-(4-Methoxyphenyl)-1,3-thiazol-4-yl]methyl}piperazine hydrochloride; (R)-1-((2-(4-Methoxyphenyl)thiazol-4-yl)methyl)piperazine hydrochloride (enantiomer specific); Piperazine, 1-[[2-(4-methoxyphenyl)-4-thiazolyl]methyl]-, hydrochloride (1:1); CAS 1052544-34-9; Thiazole-piperazine derivative hydrochloride; 4-Methoxyphenyl thiazolylmethyl piperazine HCl
EINECS	Contact for details

Quality Control

Our production of 1-[[2-(4-Methoxyphenyl)-1,3-Thiazol-4-Yl]Methyl]Piperazine Hydrochloride adheres to stringent quality management systems. Each batch undergoes comprehensive analytical characterization using HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, supporting development under ISO and cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer specific)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.