Description

3-Chloro-4-(4-Methylpiperazin-1-Yl)Aniline Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1052538-72-3. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), valued for its defined structure and consistent reactivity. It is primarily required by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development and production of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• API Synthesis: Used in multi-step synthetic routes for constructing complex molecular architectures in Active Pharmaceutical Ingredient (API) manufacturing.
• Chemical Research & Development: Serves as a versatile reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in scale-up and process development for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-Chloro-4-(4-Methylpiperazin-1-Yl)Aniline Hydrochloride
CAS No.	1052538-72-3
Molecular Formula	C11H17ClN3·HCl
Molecular Weight	280.65 g/mol
Synonyms	1-(5-Amino-2-chlorophenyl)-4-methylpiperazine hydrochloride; 3-Chloro-4-(4-methyl-1-piperazinyl)aniline hydrochloride; 3-Chloro-4-(4-methylpiperazin-1-yl)benzenamine hydrochloride; 2-Chloro-5-(4-methylpiperazin-1-yl)aniline hydrochloride; 3-Chloro-N1-(4-methylpiperazin-1-yl)benzene-1,4-diamine hydrochloride; CAS 1052538-72-3
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(4-Methylpiperazin-1-Yl)Aniline Hydrochloride is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. We support development and commercial projects with material that meets the rigorous standards required for pharmaceutical R&D and GMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.