Description

Allyl-(2-Nitro-5-Piperazin-1-Yl-Phenyl)-Amine, Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific piperazine and nitro-substituted aniline structure. This compound matters for its critical role as a key building block in the synthesis of targeted small molecule therapeutics, particularly within kinase inhibitor research and development. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material to support the creation of novel drug candidates with potential applications in oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel kinase inhibitors and other targeted small molecule drugs.
• Chemical Research & Development: Serves as a versatile building block for medicinal chemists exploring new chemical entities and structure-activity relationships.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex active pharmaceutical ingredients requiring a functionalized piperazine-aniline core.
• Bioconjugation & Probe Development: The reactive allyl amine group enables its use in creating chemical probes or conjugates for biochemical studies.

Basic Information

Product Name	Allyl-(2-Nitro-5-Piperazin-1-Yl-Phenyl)-Amine, Hydrochloride
CAS No.	1052506-28-1
Molecular Formula	C13H19N5O2 • HCl
Molecular Weight	313.78 g/mol (Free base: 277.33 g/mol)
Synonyms	1-(4-Allylamino-3-nitrophenyl)piperazine hydrochloride; N-Allyl-2-nitro-5-(piperazin-1-yl)aniline hydrochloride; 4-N-Allylamino-3-nitro-1-piperazinobenzene hydrochloride; Allyl-(2-nitro-5-piperazin-1-yl-phenyl)-amine HCl; 1052506-28-1; 4-(Allylamino)-2-nitro-N-(piperazin-1-yl)aniline hydrochloride
EINECS	Contact for details

Quality Control

Our Allyl-(2-Nitro-5-Piperazin-1-Yl-Phenyl)-Amine, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.