Description

(2S,4R)-4-Allylpyrrolidine-2-Carboxylic Acid Hydrochloride is a high-purity, non-natural amino acid derivative with a defined stereochemistry. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for pharmaceutical research and development. It is essential for chemists and researchers in the life sciences sector who require precise, enantiomerically pure scaffolds for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and bioactive probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in protease inhibitor and peptidomimetic research.
• Peptide Chemistry: Used to incorporate constrained, functionalized proline analogs into peptide chains to modulate biological activity and stability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Chemical Biology: Acts as a building block for designing enzyme inhibitors, receptor ligands, and other bioactive molecules.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in catalytic asymmetric transformations.
• Academic & Industrial R&D: Serves as a standard or starting material in methodological development and complex natural product synthesis.

Basic Information

Product Name	(2S,4R)-4-Allylpyrrolidine-2-Carboxylic Acid Hydrochloride
CAS No.	1049755-14-7
Molecular Formula	C9H15NO2 • HCl
Molecular Weight	205.68 g/mol (Free base: 169.22)
Synonyms	(2S,4R)-4-(2-Propen-1-yl)-2-pyrrolidinecarboxylic acid hydrochloride; (2S,4R)-4-Allyl-L-proline hydrochloride; 4-Allylproline hydrochloride (specifying (2S,4R) isomer); L-4-Allylproline HCl; (2S,4R)-4-(Allyl)pyrrolidine-2-carboxylic acid HCl; 1049755-14-7; Allylproline hydrochloride
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-Allylpyrrolidine-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee reproducible results for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% de (diastereomeric excess)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.