Description

(2R,5S)-1,2,5-Trimethylpiperazine is a chiral piperazine derivative of significant importance in advanced organic synthesis and pharmaceutical development. This stereochemically defined compound serves as a critical chiral building block and ligand for asymmetric catalysis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly those targeting neurological and psychiatric disorders.
• Asymmetric Catalysis: Employed as a chiral ligand or catalyst component in enantioselective synthesis to produce optically pure compounds.
• Agrochemical Research: Used in the development of novel, stereospecific pesticides and herbicides.
• Fine Chemical Synthesis: A versatile building block for creating complex natural products, flavors, and fragrances with specific stereochemistry.
• Academic & R&D: Serves as a standard or reagent in methodological development for organic and medicinal chemistry research.

Basic Information

Product Name	(2R,5S)-1,2,5-Trimethylpiperazine
CAS No.	1046788-78-6
Molecular Formula	C7H16N2
Molecular Weight	128.22 g/mol
Synonyms	(2R,5S)-1,2,5-Trimethylpiperazine; (2R,5S)-1,2,5-TMP; (2R,5S)-TMP; (2R,5S)-1,2,5-Trimethyl-piperazine; (2R,5S)-1,2,5-Trimethylhexahydropyrazine; (2R,5S)-1,2,5-TriMethylpiperazine; (2R,5S)-1,2,5-TMPIP; 1,2,5-Trimethylpiperazine (2R,5S)-isomer
EINECS	Contact for details

Quality Control

Our (2R,5S)-1,2,5-Trimethylpiperazine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.