Description

(2R,5S)-1,2,5-Trimethylpiperazine Hydrochloride CAS NO 1046788-71-9 is a high-purity, stereochemically defined chiral piperazine derivative used as a critical pharmaceutical intermediate. Its precise stereochemistry is essential for the synthesis of active pharmaceutical ingredients (APIs) with specific biological activity and reduced side-effect profiles. This compound is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in central nervous system (CNS) and antiviral drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein interactions.

Basic Information

Product Name	(2R,5S)-1,2,5-Trimethylpiperazine Hydrochloride
CAS No.	1046788-71-9
Molecular Formula	C7H17N2Cl
Molecular Weight	164.68 g/mol
Synonyms	(2R,5S)-1,2,5-Trimethylpiperazine HCl; (2R,5S)-1,2,5-Trimethylpiperazine monohydrochloride; (2R,5S)-1,2,5-Trimethylpiperazine hydrochloride salt; (2R,5S)-1,2,5-TMP HCl; (2R,5S)-1,2,5-TMP hydrochloride; (2R,5S)-1,2,5-Trimethylpiperazine chloride; (2R,5S)-1,2,5-Trimethylpiperazine HCl salt
EINECS	Contact for details

Quality Control

Our (2R,5S)-1,2,5-Trimethylpiperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.