Description

(R)-3-Isopropylamino-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral piperidine derivative, a critical building block in modern pharmaceutical synthesis. This compound matters because it provides a stereochemically defined scaffold essential for creating active pharmaceutical ingredients (APIs) with high enantiomeric purity and efficacy. Pharmaceutical R&D and fine chemical manufacturers need it for developing advanced therapeutics, particularly in central nervous system (CNS) and cardiovascular drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a versatile chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• API Development: Serves as a core structural motif in the research and scale-up production of Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Peptidomimetics: Incorporated into the design of peptide-like molecules to enhance metabolic stability and bioavailability.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals and custom molecules.

Basic Information

Product Name	(R)-3-Isopropylamino-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1044562-02-8
Molecular Formula	C13H26N2O2
Molecular Weight	242.36 g/mol
Synonyms	(R)-1-Boc-3-(isopropylamino)piperidine; (R)-N-Isopropyl-1-Boc-3-aminopiperidine; tert-Butyl (3R)-3-(isopropylamino)piperidine-1-carboxylate; (R)-3-(Isopropylamino)piperidine-1-carboxylic acid tert-butyl ester; (R)-1-N-Boc-3-(isopropylamino)piperidine; (R)-N-Isopropyl-3-amino-1-Boc-piperidine; (R)-3-Isopropylaminopiperidine-1-carboxylic acid tert-butyl ester; (R)-1-(tert-Butoxycarbonyl)-3-(isopropylamino)piperidine
EINECS	Contact for details

Quality Control

Our (R)-3-Isopropylamino-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity, meeting the stringent requirements of pharmaceutical development. All products undergo rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.