Description

1-Hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-Docosahexaenoyl)-Sn-Glycero-3-Phosphoethanolamine is a high-purity, synthetic phospholipid featuring a saturated palmitic acid (C16:0) at the sn-1 position and the essential ω-3 fatty acid docosahexaenoic acid (DHA, C22:6) at the sn-2 position. This specific molecular architecture makes it a critical building block for advanced lipid-based delivery systems and a vital tool for membrane biophysics research. It is primarily sought by pharmaceutical R&D teams, nutraceutical formulators, and academic researchers developing next-generation liposomes, lipid nanoparticles (LNPs), and model membrane studies.

Application

• Drug Delivery System Formulation: A key phospholipid component for constructing stealth liposomes and lipid nanoparticles (LNPs) for targeted and sustained release of active pharmaceutical ingredients (APIs).
• Nutraceutical & Cosmeceutical Encapsulation: Used to create stable, bioavailable delivery vehicles for sensitive compounds like ω-3s, vitamins, and antioxidants in functional food and high-end skincare products.
• Membrane Biophysics & Cell Biology Research: Essential for synthesizing asymmetric model membranes to study lipid raft formation, protein-lipid interactions, and membrane fluidity dynamics.
• Biomimetic Coatings & Sensors: Serves as a precursor for creating supported lipid bilayers (SLBs) used in biosensor development, diagnostic platforms, and biocompatible surface coatings.
• Exosome & Vesicle Mimetics: Employed in the production of synthetic exosomes and extracellular vesicle mimetics for therapeutic and diagnostic applications.
• Reference Standard & Analytical Chemistry: Used as a high-purity certified reference material (CRM) for method development, calibration, and quality control in lipidomics and pharmaceutical analysis.

Basic Information

Item	Details
Product Name	1-Hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-Docosahexaenoyl)-Sn-Glycero-3-Phosphoethanolamine
CAS No.	1042142-84-6
Molecular Formula	C43H74NO8P
Molecular Weight	764.02 g/mol
Synonyms	16:0-22:6 PE; 1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine; PDPE; PE(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); 1-Palmitoyl-2-DHA-sn-glycero-3-phosphoethanolamine; DHA-containing Phosphatidylethanolamine; (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic Acid, 1-hexadecanoyl-2-[(1-oxo-4,7,10,13,16,19-docosahexaen-1-yl)]-sn-glycero-3-phosphoethanolamine; Phosphatidylethanolamine (16:0/22:6)
EINECS	Contact for details

Quality Control

Every batch of our phospholipids is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing results from advanced techniques including HPLC, NMR, and MS. Our production adheres to cGMP guidelines where applicable, supporting use in pharmaceutical and advanced therapeutic development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (HPLC-MS)	Complies
Identification (NMR)	Complies
Assay (HPLC)	≥ 95.0%
Solvent Content (Residual Solvents)	≤ 2.0%
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 5.0 meq/kg
Fatty Acid Profile (GC)	Confirms 16:0 and 22:6 composition

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.