Description

8-tert-Butyl 2-Methyl 8-Azabicyclo[3.2.1]Oct-2-Ene-2,8-Dicarboxylate is a high-value, advanced pharmaceutical intermediate belonging to the class of functionalized azabicyclic compounds. This compound is critical for the synthesis of complex molecules, particularly in medicinal chemistry where its rigid, three-dimensional scaffold is leveraged to modulate biological activity and improve drug-like properties. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including central nervous system (CNS) drugs and alkaloid-based pharmaceuticals.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those with tropane or related alkaloid structures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space for drug discovery programs.
• Asymmetric Synthesis: Utilized as a chiral precursor or template in the development of stereoselective synthetic routes due to its bicyclic framework.
• CNS Drug Development: Applied in the research and development of potential therapeutics targeting neurological disorders.
• Chemical Biology Probes: Acts as a core structure for designing molecular probes to study biological pathways and enzyme functions.
• Process Chemistry: Employed in the scale-up and route scouting for the commercial manufacturing of complex drug candidates.

Basic Information

Product Name	8-tert-Butyl 2-Methyl 8-Azabicyclo[3.2.1]Oct-2-Ene-2,8-Dicarboxylate
CAS No.	1033820-27-7
Molecular Formula	C15H23NO4
Molecular Weight	281.35 g/mol
Synonyms	8-Azabicyclo[3.2.1]oct-2-ene-2,8-dicarboxylic acid, 2-methyl-, 8-(1,1-dimethylethyl) ester; tert-Butyl 2-methyl-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate-2-carboxylate; 2-Methyl-8-azabicyclo[3.2.1]oct-2-ene-2,8-dicarboxylic acid 8-tert-butyl ester 2-methyl ester; 8-tert-Butyl 2-methyl 8-azabicyclo[3.2.1]oct-2-ene-2,8-dicarboxylate; Bicyclic tropane derivative intermediate; 8-Boc-2-COOMe azabicyclo[3.2.1]octene
EINECS	Contact for details

Quality Control

Our production of 8-tert-Butyl 2-Methyl 8-Azabicyclo[3.2.1]Oct-2-Ene-2,8-Dicarboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized and released against comprehensive specifications. A Certificate of Analysis (COA) detailing identity, purity (typically by HPLC), and impurity profile is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.