Description

[1-(2,3-Difluoro-Benzyl)-3-Oxo-Piperazin-2-Yl]-Acetic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its piperazinone-acetic acid core and difluorobenzyl substituent. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Used in the final stages or penultimate steps for constructing target molecules with specific chiral centers and fluorinated aromatic groups.
• Bioconjugation & Prodrug Development: The acetic acid moiety allows for further functionalization, making it suitable for creating prodrugs or antibody-drug conjugates (ADCs).
• Chemical Reference Standard: Supplied as a certified reference material for analytical method development, validation, and quality control in GMP manufacturing.
• Academic & Industrial R&D: Employed in exploratory chemistry for developing new synthetic methodologies and novel heterocyclic compounds.

Basic Information

Product Name	[1-(2,3-Difluoro-Benzyl)-3-Oxo-Piperazin-2-Yl]-Acetic Acid
CAS No.	1033600-07-5
Molecular Formula	C14H16F2N2O3
Molecular Weight	298.29 g/mol
Synonyms	2-[[1-[(2,3-Difluorophenyl)methyl]-3-oxo-2-piperazinyl]acetic acid; 2-(1-(2,3-Difluorobenzyl)-3-oxopiperazin-2-yl)acetic acid; (1-(2,3-Difluorobenzyl)-3-oxopiperazin-2-yl)acetic acid; 1033600-07-5; 1-(2,3-Difluorobenzyl)-3-oxopiperazine-2-acetic acid; UNII-0L3R9Q5K2F; 0L3R9Q5K2F; SCHEMBL2188046; AKOS040759789
EINECS	Contact for details

Quality Control

Our [1-(2,3-Difluoro-Benzyl)-3-Oxo-Piperazin-2-Yl]-Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and cGMP intermediate production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation are provided for full traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is compatible with strong acid/organic solvent environments but should be kept separate from strong bases and oxidizing agents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.