Description

[1-(2-Fluoro-Benzyl)-3-Oxo-Piperazin-2-Yl]-Acetic Acid is a high-purity pharmaceutical intermediate characterized by its piperazinone-acetic acid core structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the generation of compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for GMP production of target molecules.
• Bioconjugation & Probe Development: The acetic acid moiety allows for functionalization and conjugation, making it useful for creating biochemical probes or antibody-drug conjugates (ADC) linkers.

Basic Information

Product Name	[1-(2-Fluoro-Benzyl)-3-Oxo-Piperazin-2-Yl]-Acetic Acid
CAS No.	1033600-04-2
Molecular Formula	C14H17FN2O3
Molecular Weight	280.30 g/mol
Synonyms	2-[(1-(2-Fluorobenzyl)-3-oxopiperazin-2-yl]acetic acid; 2-[1-[(2-Fluorophenyl)methyl]-3-oxopiperazin-2-yl]acetic acid; (1-(2-Fluorobenzyl)-3-oxo-2-piperazinyl)acetic acid; 1033600-04-2; 1-(2-Fluorobenzyl)-3-oxopiperazine-2-acetic acid; 2-(1-(2-Fluorobenzyl)-3-oxopiperazin-2-yl)acetic acid
EINECS	Contact for details

Quality Control

Our [1-(2-Fluoro-Benzyl)-3-Oxo-Piperazin-2-Yl]-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.