Description

[1-(3-Fluoro-Benzyl)-3-Oxo-Piperazin-2-Yl]-Acetic Acid is a high-purity, non-natural amino acid derivative featuring a piperazinone core, which is a privileged scaffold in medicinal chemistry. This compound is a critical pharmaceutical intermediate for the research and development of novel therapeutic agents, particularly in areas requiring precise molecular modification. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Protease Inhibitor Research: Used in the development of inhibitors for enzymes like DPP-4, as the piperazinone structure is common in such pharmacophores.
• Peptidomimetic Chemistry: Serves as a constrained dipeptide surrogate to enhance the metabolic stability and bioavailability of peptide-based drugs.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of APIs (Active Pharmaceutical Ingredients) under cGMP conditions.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and medicinal chemistry projects.

Basic Information

Product Name	[1-(3-Fluoro-Benzyl)-3-Oxo-Piperazin-2-Yl]-Acetic Acid
CAS No.	1033399-99-3
Molecular Formula	C14H17FN2O3
Molecular Weight	280.30 g/mol
Synonyms	2-[[1-[(3-Fluorophenyl)methyl]-3-oxo-2-piperazinyl]]acetic Acid; 2-([1-[(3-Fluorophenyl)methyl]-3-oxopiperazin-2-yl])acetic Acid; (1-[(3-Fluorobenzyl)-3-oxopiperazin-2-yl])acetic Acid; 1-(3-Fluorobenzyl)-3-oxopiperazine-2-acetic Acid; 1033399-99-3; (1-(3-Fluorobenzyl)-3-oxopiperazin-2-yl)acetic acid
EINECS	Contact for details

Quality Control

Our [1-(3-Fluoro-Benzyl)-3-Oxo-Piperazin-2-Yl]-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurities, and other critical parameters. Our quality commitment supports applications in cGMP-compliant pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.