Description

(2R)-1-Methanesulfonyl-2-Methylpiperazine Hydrochloride is a high-purity chiral piperazine derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in its role as a key intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of complex drug candidates, especially in central nervous system (CNS) and oncology research.
• API Development: Serves as a building block in the construction of novel Active Pharmaceutical Ingredients (APIs) requiring a specific (R)-configured methylpiperazine moiety.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and cGMP manufacturing of clinical trial materials and commercial drugs.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a defined stereochemical center for molecular modification.
• Asymmetric Synthesis: Acts as a chiral auxiliary or precursor in catalytic asymmetric reactions to introduce molecular complexity.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in regulatory filings.

Basic Information

Product Name	(2R)-1-Methanesulfonyl-2-Methylpiperazine Hydrochloride
CAS No.	1032757-87-1
Molecular Formula	C6H14N2O2S • HCl
Molecular Weight	238.71 g/mol
Synonyms	(R)-1-Methanesulfonyl-2-methylpiperazine hydrochloride; (2R)-2-Methyl-1-(methylsulfonyl)piperazine hydrochloride; (R)-2-Methyl-1-(methylsulfonyl)piperazine HCl; 1-(Methylsulfonyl)-2-methyl-(2R)-piperazine hydrochloride; (R)-Ms-2-methylpiperazine hydrochloride; Piperazine, 1-(methylsulfonyl)-2-methyl-, (2R)-, hydrochloride; UNII-9H3U8G3F5F
EINECS	Contact for details

Quality Control

Our (2R)-1-Methanesulfonyl-2-Methylpiperazine Hydrochloride is manufactured under strict quality systems suitable for pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles. We ensure compliance with relevant ICH guidelines and can support regulatory filings with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.