Description

(R)-2-Hydroxymethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a chiral piperazine derivative and a crucial protected intermediate in organic synthesis. This compound matters for its role as a versatile building block in the development of complex, biologically active molecules, particularly in the pharmaceutical sector. It is primarily needed by research institutions and manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used as a building block for developing advanced pesticides and herbicides with specific stereochemical requirements for enhanced activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Employed in the design and synthesis of peptidomimetic compounds to modulate protein-protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, enantiomerically pure intermediates.
• Academic and R&D Laboratories: Utilized in medicinal chemistry and process chemistry research for exploring new synthetic routes and methodologies.

Basic Information

Product Name	(R)-2-Hydroxymethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1030377-21-9
Molecular Formula	C11H22N2O3
Molecular Weight	230.31 g/mol
Synonyms	(R)-1-Boc-2-(hydroxymethyl)piperazine; (R)-N-Boc-2-(hydroxymethyl)piperazine; (R)-2-(Hydroxymethyl)-1-(tert-butoxycarbonyl)piperazine; tert-Butyl (R)-2-(hydroxymethyl)piperazine-1-carboxylate; (R)-1-N-Boc-2-piperazinemethanol; (R)-2-Hydroxymethyl-1-Boc-piperazine; (R)-2-Piperazinemethanol, 1-(1,1-dimethylethoxy)carbonyl-; (R)-2-(Hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxymethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee consistent quality, identity, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.