Description

Trelagliptin Succinate CAS NO 1029877-94-8 is a high-purity active pharmaceutical ingredient (API) and a key intermediate in the synthesis of advanced antidiabetic therapeutics. It serves as the succinate salt form of Trelagliptin, offering enhanced stability and formulation properties for pharmaceutical manufacturing. This compound is essential for research institutions and pharmaceutical companies engaged in the development and production of novel Dipeptidyl Peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes.

Application

• Pharmaceutical API Synthesis: Primary active ingredient for the formulation of once-weekly oral antidiabetic medications.
• DPP-4 Inhibitor Research: Critical reference standard and building block in metabolic disease and enzymology research.
• Drug Development Intermediates: Used in the scaled-up synthesis and process optimization of novel incretin-based therapies.
• Analytical Reference Standard: Serves as a high-purity calibrant for HPLC, LC-MS, and other analytical methods in quality control laboratories.
• Formulation Studies: Employed in pre-formulation and stability testing for solid dosage forms like tablets and capsules.

Basic Information

Product Name	Trelagliptin Succinate
CAS No.	1029877-94-8
Molecular Formula	C24H30FN5O2 • C4H6O4
Molecular Weight	573.61 g/mol
Synonyms	2-({6-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)-4-fluorobenzonitrile succinate; Trelagliptin hydrogen succinate; Succinic acid compound with 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)-4-fluorobenzonitrile (1:1); Zafatek (brand name intermediate); T-6665; TAK-6665
EINECS	Contact for details

Quality Control

Our Trelagliptin Succinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological quality is provided with every shipment to ensure full traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.