Description

(R,S)-4-Fmoc-3-Carboxymethyl-Piperazin-2-One is a key, high-purity building block used in the synthesis of complex organic molecules. Its value lies in its dual functionality, featuring both an Fmoc-protected amine and a carboxylic acid group, which enables precise and versatile peptide coupling and molecular scaffold construction. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel peptide-based therapeutics, protease inhibitors, and constrained peptidomimetics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) for drug discovery and development.
• Peptide Synthesis: Serves as a constrained, non-natural amino acid derivative for constructing complex peptide chains in solid-phase and solution-phase peptide synthesis (SPPS).
• Protease Inhibitor Development: Used to create molecular scaffolds that mimic peptide substrates, aiding in the design of inhibitors for enzymes like HIV protease.
• Chemical Biology & Bioconjugation: Employed in the synthesis of chemical probes and linkers for studying protein-protein interactions and creating antibody-drug conjugates (ADCs).
• Combinatorial Chemistry: A valuable building block for generating diverse chemical libraries for high-throughput screening.
• Academic & Industrial Research: Used in R&D laboratories for exploring new synthetic methodologies and novel bioactive compounds.

Basic Information

Product Name	(R,S)-4-Fmoc-3-Carboxymethyl-Piperazin-2-One
CAS No.	1029630-75-8
Molecular Formula	C22H22N2O5
Molecular Weight	394.42 g/mol
Synonyms	4-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(carboxymethyl)-2-piperazinone; 3-(Carboxymethyl)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-piperazinone; 4-Fmoc-3-(carboxymethyl)-2-piperazinone; 4-Fmoc-3-carboxymethyl-2-piperazinone; 4-Fmoc-3-carboxymethylpiperazin-2-one; Fmoc-Cmp-OH; (Rac)-4-Fmoc-3-carboxymethyl-2-piperazinone
EINECS	Contact for details

Quality Control

Our (R,S)-4-Fmoc-3-Carboxymethyl-Piperazin-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.