Description

1-n-Boc-(2R,4R)-4-Hydroxy-2-(Hydroxymethyl) Piperidine is a high-purity, chiral piperidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for the development of complex pharmaceutical molecules, particularly in the creation of active pharmaceutical ingredients (APIs) and novel drug candidates. It is primarily utilized by research institutions and pharmaceutical manufacturers specializing in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex APIs, especially for neurological and antiviral therapeutics.
• Asymmetric Synthesis: Used as a versatile building block for constructing chiral centers in complex natural products and bioactive molecules.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies for new drug discovery programs.
• Peptidomimetics Development: Serves as a constrained scaffold for designing and synthesizing peptide mimics with enhanced metabolic stability.
• Catalyst and Ligand Synthesis: A precursor for developing novel chiral catalysts and ligands used in enantioselective transformations.
• Custom Synthesis Projects: Provided to contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis.

Basic Information

Product Name	1-n-Boc-(2R,4R)-4-Hydroxy-2-(Hydroxymethyl) Piperidine
CAS No.	1029429-49-9
Molecular Formula	C12H23NO4
Molecular Weight	245.32 g/mol
Synonyms	(2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)piperidine; (2R,4R)-1-Boc-4-hydroxy-2-piperidinemethanol; tert-Butyl (2R,4R)-4-hydroxy-2-(hydroxymethyl)piperidine-1-carboxylate; 1-Boc-4-hydroxy-2-hydroxymethylpiperidine (2R,4R); (2R,4R)-1-N-Boc-4-hydroxy-2-hydroxymethylpiperidine; (2R,4R)-4-Hydroxy-2-(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; (2R,4R)-1-Boc-4-hydroxy-2-piperidinylmethanol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is analyzed using advanced chromatographic and spectroscopic techniques to guarantee identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request, detailing comprehensive specifications including chiral purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.