Description

Peg8-Tos CAS NO 1028089-05-5 is a specialized polyethylene glycol (PEG) derivative functionalized with a tosylate (p-toluenesulfonate) group at one terminus. This bifunctional molecule is a critical intermediate in organic synthesis and bioconjugation, offering a reactive handle for nucleophilic substitution reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating PEGylated compounds, cross-linkers, and functional polymers.

Application

• Pharmaceutical Intermediate: Acts as a key building block for synthesizing active pharmaceutical ingredients (APIs) and prodrugs requiring PEGylation.
• Bioconjugation Reagent: Used to attach polyethylene glycol chains to proteins, peptides, or antibodies to improve solubility, stability, and circulation time.
• Polymer Chemistry: Serves as a functional initiator or monomer in the synthesis of block copolymers and functionalized polymeric materials.
• Cross-linking Agent: Employed in the preparation of hydrogels, polymer networks, and surface modifications due to its reactive tosylate group.
• Surface Functionalization: Used to modify nanoparticles, quantum dots, or other nanomaterials to enhance biocompatibility and targeting.
• Linker for Solid-Phase Synthesis: Applicable in peptide and oligonucleotide synthesis as a cleavable or functional linker.

Basic Information

Item	Detail
Product Name	Peg8-Tos
CAS No.	1028089-05-5
Molecular Formula	C23H40O11S
Molecular Weight	524.62 g/mol
Synonyms	8-Aza-3,6,9,12,15,18,21,24-octaoxapentacosan-1-yl 4-methylbenzenesulfonate; Poly(ethylene glycol) 8-monotosylate; PEG8 Monotosylate; α-Methyl-ω-tosyl-poly(ethylene glycol) (n=8); mPEG8-Tosylate; 4-Methylbenzenesulfonic acid 2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl ester; Tos-PEG8-OH; PEG8 OTs
EINECS	Contact for details

Quality Control

Our Peg8-Tos is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and production. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.