Description

tert-Butyl 4-(5-Iodopyrimidin-2-Yl)Piperazine-1-Carboxylate is a high-value, heterocyclic building block featuring a piperazine core protected by a Boc (tert-butoxycarbonyl) group and a 5-iodopyrimidine moiety. This compound is essential for medicinal chemistry research and development, serving as a versatile intermediate for the synthesis of targeted small molecule libraries. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the discovery of novel therapeutic agents, particularly in kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of kinase inhibitors and other biologically active small molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable iodine and protected amine functionalities.
• Chemical Biology Probes: Serves as a scaffold for creating molecular probes to study enzyme function and cellular pathways.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse aromatic and alkyne groups.
• Peptidomimetic Synthesis: The Boc-protected piperazine is a valuable component in the design of peptidomimetics and conformationally constrained analogs.
• Library Synthesis: Enables the rapid generation of compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	tert-Butyl 4-(5-Iodopyrimidin-2-Yl)Piperazine-1-Carboxylate
CAS No.	1027616-32-5
Molecular Formula	C13H18IN5O2
Molecular Weight	403.22 g/mol
Synonyms	1-Boc-4-(5-iodopyrimidin-2-yl)piperazine; 2-(1-Boc-piperazin-4-yl)-5-iodopyrimidine; tert-Butyl 4-(5-iodo-2-pyrimidinyl)-1-piperazinecarboxylate; 5-Iodo-2-(4-Boc-piperazin-1-yl)pyrimidine; 1-(tert-Butoxycarbonyl)-4-(5-iodopyrimidin-2-yl)piperazine; Boc-4-(5-iodo-2-pyrimidyl)piperazine; 1027616-32-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-Iodopyrimidin-2-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.