Description

Rac Ketorolac 6-Benzoyl Isomer CAS NO 1026936-07-1 is a key stereoisomeric intermediate in the synthesis of the potent non-steroidal anti-inflammatory drug (NSAID) Ketorolac. This compound is of critical importance for pharmaceutical research and development, particularly in the study of chirality, metabolic pathways, and the pharmacological activity of individual enantiomers. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced analytical method development and process chemistry for novel NSAID formulations.

Application

• Pharmaceutical Reference Standard: Serves as a critical analytical standard for the identification, purity assessment, and quantification of the 6-benzoyl isomer in Ketorolac drug substances and related impurities.
• Process Chemistry R&D: Used in the research and development of stereoselective synthesis routes for Ketorolac tromethamine, aiding in yield optimization and impurity profile control.
• Metabolic Studies: Employed in preclinical and clinical research to investigate the pharmacokinetics, distribution, and excretion of specific Ketorolac isomers.
• Analytical Method Development: Essential for developing and validating chromatographic methods (HPLC, LC-MS) to separate and characterize Ketorolac enantiomers and their degradation products.
• Impurity Profiling: Acts as a certified impurity standard to monitor and control the quality of bulk Ketorolac API (Active Pharmaceutical Ingredient) during manufacturing.
• Academic Research: Utilized in university and institutional labs for studies on NSAID mechanisms of action, structure-activity relationships (SAR), and isomer-specific effects.

Basic Information

Product Name	Rac Ketorolac 6-Benzoyl Isomer
CAS No.	1026936-07-1
Molecular Formula	C19H24N2O4
Molecular Weight	344.41 g/mol
Synonyms	(±)-5-Benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid; rac 6-Benzoyl Ketorolac; Ketorolac 6-Benzoyl Isomer Racemate; 2-(6-Benzoyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetic acid (racemic); Ketorolac Impurity F (Racemate); 6-Benzoyl Ketorolac Racemic Mixture; 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-acetic Acid
EINECS	Contact for details

Quality Control

Our Rac Ketorolac 6-Benzoyl Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, chiral chromatography for isomeric composition, and structural confirmation (NMR, MS) to ensure identity and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, supporting compliance with ICH guidelines for impurities in pharmaceutical substances.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive material from prolonged exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isomeric Purity (Chiral HPLC)	Racemic mixture (50:50 ± 2%)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.